Upregulation of the mammalian X chromosome is associated with enhanced transcription initiation, MOF-mediated H4K16 acetylation, and longer RNA half-life
نویسندگان
چکیده
Xinxian Deng1, Joel B. Berletch1, Wenxiu Ma2, Di Kim Nguyen1, William S. Noble2,3, Jay Shendure2, and Christine M. Disteche1,4,* 1Department of Pathology, University of Washington School of Medicine, Seattle, Washington, United States of America 2Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America 3Department of Computer Science and Engineering, University of Washington, Seattle, Washington, United States of America 4Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
منابع مشابه
Modulation of ISWI function by site-specific histone acetylation.
Mutations in Drosophila ISWI, a member of the SWI2/SNF2 family of chromatin remodeling ATPases, alter the global architecture of the male X chromosome. The transcription of genes on this chromosome is increased 2-fold relative to females due to dosage compensation, a process involving the acetylation of histone H4 at lysine 16 (H4K16). Here we show that blocking H4K16 acetylation suppresses the...
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Hypoacetylated H4 is present at regional centromeres; however, its role in kinetochore function is poorly understood. We characterized H4 acetylation at point centromeres in Saccharomyces cerevisiae and determined the consequences of altered H4 acetylation on chromosome segregation. We observed low levels of tetra-acetylated and K16 acetylated histone H4 (H4K16Ac) at centromeres. Low levels of ...
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تاریخ انتشار 2013